Tuesday, October 18, 2005

Killer Cell Trial

Yesterday we saw the BMT doctor at the adult's hospital to discuss the killer cell trial. This is a phase I dose escalation study with a procedure very similar to the DLIs that Adrienne has already had. In fact, they describe it as a targeted DLI where the natural killer (NK) cells are given cytokines to make them reproduce up to 400 times. The biggest issue appears to be scheduling. They only treat one patient a month and Adrienne has her hip surgery at the next available date in December. We're going to propose a week in January after Adrienne has a chance to heal and before she returns to school, and a date in March when she's home from school for a break.

Adrienne's chest xray was clear of disease and her labs were great except that her lymphocyte count was quite low. I was curious about it because she's been getting lymphocyte infusions. It turns out that radiation destroys lymphocytes so Adrienne still needs to be careful about being around sick people. Otherwise, everything is perfect. Adrienne had an echo yesterday also that turned out to be quite a production. First, it started nearly 90 minutes late. Then, Adrienne had a student who had a hard time completing the test, and finally the power went out. After over an hour (this usually takes 20 minutes), they let Adrienne go without all the pictures they needed. Hopefully it will be enough for her surgery in December.

Rachel asked about Adrienne's major. Hmmm, that's sort of a fluid question. Right now she's interested in Psychology with a sequence (like a minor) in Leadership Studies, a unique program at CMC. Adrienne works at the Kravis Leadership Institute and has become very interested in the sequence, which has quite a bit of overlap with psychology. She can do a summer internship at the Kravis Institute as part of the sequence, which would be a great experience. This summer, we are considering a study abroad program in Spain that focuses on intensive Spanish language studies and Spanish culture. Most students spend their junior year abroad but, with Adrienne's health issues, that would be impossible.

Rachel: Can you send me your e-mail address and Darin's at garnett@garnettgrp.com?

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