"The Plan"

I put "the plan" in quotes because things are still up in the air. We had a long talk with Adrienne's onc on Wednesday with the intent to go back on the trial, adding IV hydration twice a week, while watching things very closely. At the first sign of trouble, the plan is to go off. After this discussion, we reviewed Adrienne's labs and for some reason her kidney function was way up (up is bad with kidney function). She got hydration yesterday and today in hopes that her numbers come down but it's possible she won't be able to start treatment on Monday no matter what, and then she's off the trial permanently.

Of course, we discussed next steps if she goes off the trial. Both her onc here and her onc at City of Hope think chemo is a bad idea, that it will only suppress her marrow, and give her no benefit in terms of reducing her disease. In all probability, we'd choose to stop treatment for awhile and then enroll in another clinical trial when her disease starts to grow again. SGN-35 is showing great promise but they aren't allowing patients with allo transplants and they aren't granting compassionate use applications. But you know me, I'm not going to give up that easily so I'm working on a strategy to put pressure on the company to give Adrienne the drug outside of a clinical trial.

Otherwise, things are fine here. The weather is absolutely gorgeous and Adrienne is feeling well enough again to get out. School is going great for her although she misses the challenge of CMC. Daniel has recovered from his dog bite and the dog is now in "pit bull rehab." The other choices were to put the dog down or keep him in a full body muzzle. Hopefully this dog won't hurt anyone again.